CHINESE 
ENGLISH
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Veterinary APIs
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Intermediates
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PRODUCTS
Properties
CAS NO : 217500-96-4
Molecular Formula : C41H79N3O12
Structural Formula:
217500-96-4 Properties
- Molecular Formula:C41H79N3O12
- Molecular Weight:806.091
- Boiling Point:853.8±65.0 °C(Predicted)
- PKA:13.19±0.70(Predicted)
- PSA：200.90000
- Density:1.17
- LogP:2.64800
217500-96-4 Usage
Chemical Properties
White Solid
Uses
Tulathromycin A is used for the treatment of pulmonary diseases in pigs and cattle. In cattle, tulathromycin is used for the treatment of rinderpest caused by Haemolytic rinderpest, polyvalent rinderpest and Haemophilus somnus (formerly Haemophilus somnus). It is also effective in the treatment of infections caused by Mycoplasma bovis. When used in high-risk calves, it is also used to prevent infections caused by these pathogens. It is also used for the treatment of bovine foot rot (interdigital necrotizing fungal disease) associated with Fusarium necrophorum and Fusarium oxysporum. A single dose is effective in bovine infectious keratoconjunctivitis (Mycobacterium bovis).In pigs, it is used to control and treat SRD associated with Actinobacillus pleuropneumoniae, Bacteroides multilocularis, Bordetella bronchiseptica, Mycoplasma pneumoniae, and Haemophilus parasiticus, and tulathromycin has been used to treat lung abscesses.
Description
Tulathromycin A is a triamide antibiotic used for the treatment of respiratory diseases in cattle and pigs. It exists as a balanced mixture of two isomers. Tulathromycin is an antimicrobial agent of a macrolide, a 15-membered macrolide structure that is considered a triamide macrolide with three charged nitro groups.
Definition
ChEBI:Tulathromycin A is an aminoglycoside.
217500-96-4 Relevant articles
Synthesis of terramycin
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Paragraph 0020-0021, (2022/01/08)
The present invention relates to the synthesis of terramycin, specifically (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-[[3S,4S,6R,8R]-8-methoxy-4,8-dimethyl-1,5-dioxa snail [2,5]octyl-6-yl]oxo) 3,5,8,10,12,14-hexamethyl-11-[3,4, 6-Tr
Preparation method of tulathromycin
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Paragraph 0022-0033, (2021/05/05)
The invention relates to a synthetic method of tulathromycin. Under the action of illumination and a specific catalytic system, rapid, efficient and pollution-free synthesis of tulathromycin is realized. Compared with the existing synthetic method, the synthetic method provided by the invention is simple to operate, mild in condition and capable of meeting the requirement of large-scale industrial production.
Preparation method of tulathromycin
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Paragraph 0058-0060, (2020/04/02)
The invention provides a preparation method of tulathromycin, and belongs to the field of pharmaceutical chemicals. The method comprises the following steps of: reacting azithromycin serving as a rawmaterial with phenyl chloroformate to protect hydroxyl to obtain protected nitrogen azithromycin, oxidizing the hydroxyl into a ketone group by oxidation, epoxidizing, deprotecting, and reacting withn-propylamine to obtain tulathromycin. The product produced by the method has the characteristics of high purity, high yield, low cost, simple operation and stable process.
Method for synthesizing oxytetracycline and oxytetracycline phosphate (by machine translation)
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Paragraph 0052-0056, (2020/04/22)
Step A product shown in Formula is obtained by dissolving, a product of: Formula I with a product shown by subjecting a product shown II in Formula to a reaction; to obtain a product having a hydroxyl: protection product II as shown in Formula I, and a ca
217500-96-4 Process route
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- 107-10-8,42939-71-9
propylamine
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(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]octan-6-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
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- 217500-96-4
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[[2,6-dideoxy-3-C-methyl-3-Ο-methyl-4-C-[(propylamino)methyl]-α-L-ribohexopyranosyl]oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylohexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
| Conditions | Yield |
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at 60 ℃;
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94% |
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propylamine; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((3S,4S,6R,8R)-8-methoxy-4,8-dimethyl-1,5-dioxaspiro[2.5]octan-6-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one; In isopropyl alcohol; at 55 ℃; for 20h;
With phosphoric acid; In ethanol; water; acetone; for 12h;
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82.1% |
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With ytterbium(III) triflate; In isopropyl alcohol; at 50 ℃; for 3h;
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75.2% |
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In 2-methyl-propan-1-ol; at 55 - 65 ℃;
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In propylene glycol; at 45 - 55 ℃; for 20h; Temperature; Time; Solvent; Inert atmosphere;
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C41H77N3O12
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- 217500-96-4
tulathromycin
| Conditions | Yield |
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With ammonia; hydrogen; In methanol; at 50 ℃; for 5h; under 3750.38 Torr; Reagent/catalyst; Temperature; Autoclave; Sealed tube;
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93% |
217500-96-4 Upstream products
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107-10-8
propylamine
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217649-77-9
carbonic acid benzyl ester 4-dimethylamino-2-[2-ethyl-3,4,10-trihydroxy-13-(8-methoxy-4,8-dimethyl-1,5-dioxa-spiro[2.5]oct-6-yloxy)-3,5,8,10,12,14-hexamethyl-15-oxo-1-oxa-6-aza-cyclopentadec-11-yloxy]-6-methyl-tetrahydro-pyran-3-yl ester
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111321-02-9
erythromycin A 9-(E)-oxime
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76801-85-9
9-Deoxo-9a-aza-9a-homoerythromycin A